Does an acute bout of high intensity interval exercise suppress appetite in obese women?

Keywords: obesity, appetite, energy intake, AgRP, intensity interval exercise

Abstract

Purpose: The aim of this study was to investigate the 24 hour response of appetite and energy intake and the amount of Agouti-Related Protein to the high intensity interval exercise in obese untrained women. Methods: Ten obese untrained women were voluntarily selected according to the criteria of the research and evaluated in two experimental and control sessions. Blood samples were collected in two sessions of control and experimental group in five stages. Also, the appetite questionnaire was completed in 9 steps. Also, energy intake was recorded by them during the day. Results: Agouti-Related Protein increased significantly in experimental session immediately after exercise compared to the control session (p<0.05). In the Visual analog scale, the feeling of hunger and desire to eat decreased significantly immediately after exercise and before lunch in the experimental session (p<0.05). While feeling of satiety and fullness were significantly higher immediately after exercise and before lunch (p<0.05), in other words, the desire to eat was reduced. Also, exercise significantly reduced energy intake in the experimental session compared to control session (p<0.05). The amount of protein consumption, carbohydrate, and fat decreased in the experimental session compared to the control session, but this decrease was not statistically significant (p>0.05). Conclusions: Although a session of high intensity interval exercise resulted in reduced energy intake, but this reduction was not related to just one macronutrient. Hunger and desire to eat decreased after exercise and before lunch but the Agouti-Related Protein increased after exercise.

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Author Biographies

Sepideh Khalaj, University of Guilan
Sepideh_khalaj@yahoo.com; Faculty of Physical Education and Sport Sciences; P.O Box: 1438, Rasht, Iran.
Bahman Mirzaei, University of Guilan
mirzaei@united-world-wrestling.org; Professor in exercise physiology;  Faculty of Physical Education and Sport Sciences; P.O Box: 1438, Rasht, Iran.

References

1. Matos V, Souza D, Santos V, Medeiros Í, Browne R. Nascimento, P., et al. Acute effects of high-intensity interval and moderate-intensity continuous exercise on glp-1, appetite and energy intake in obese men: A crossover trial. Nutrients, 2018; 10.7: 889.
https://doi.org/10.3390/nu10070889

2. Lohmann AE, Goodwin PJ, Chlebowski RT, Pan K, Stambolic V, Dowling RJ. Association of obesity-related metabolic disruptions with cancer risk and outcome. Journal of Clinical Oncology, 2016; 34.35: 4249- 4255.‏
https://doi.org/10.1200/JCO.2016.69.6187‏

3. Atkins JL. Effects of Sarcopenic Obesity on Cardiovascular Disease and All-Cause Mortality. In: Nutrition and Skeletal Muscle. Academic Press, 2019; p. 93-103.
https://doi.org/10.1016/B978-0-12-810422-4.00007-5

4. Ohnishi H, Saitoh S. Obesity and Diabetes Mellitus as Risk Factors for Cardiovascular Disease in the Elderly. In: Health Issues and Care System for the Elderly. Springer, Singapore, 2019; p. 97-106.
https://doi.org/10.1007/978-981-13-1762-0_7

5. Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M. Obesity and cancer risk: Emerging biological mechanisms and perspectives. Metabolism, 2019; 92: 121-135. https://doi.org/10.1016/j.metabol.2018.11.001

6. Piaggi P, Vinales KL, Basolo A, Santini F, Krakoff J. Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms. Journal of endocrinological investigation, 2018; 41.1: 83-89.
https://doi.org/10.1007/s40618-017-0732-9

7. Larsen PS, Donges CE, Guelfi KJ, Smith GC, Adams DR, Duffield R. Effects of aerobic, strength or combined exercise on perceived appetite and appetite-related hormones in inactive middle-aged men. International journal of sport nutrition and exercise metabolism, 2017; 27.5: 389-398.
.https://doi.org/10.1123/ijsnem.2017-0144

8. Timper K, Brüning JC. Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Disease models & mechanisms, 2017; 10.6: 679-689.‏
https://doi.org/10.1242/dmm.026609‏

9. Williams G, Cai XJ, Elliott JC, Harrold JA. Anabolic neuropeptides. Physiology & behavior, 2004, 81.2: 211-222.‏
https://doi.org/10.1016/j.physbeh.2004.02.005

10. Bai F, Sözen MA, Lukiw WJ, Argyropoulos G. Expression of AgRP, NPY, POMC and CART in human fetal and adult hippocampus. Neuropeptides, 2005; 39.4: 439-443.‏‏
https://doi.org/10.1016/j.npep.2005.02.007

11. Martins C, Stensvold D, Finlayson G, Holst J, Wisloff U, Kulseng B, et al. Effect of moderate-and high-intensity acute exercise on appetite in obese individuals. Medicine & Science in Sports & Exercise, 2015; 47.1: 40-48.‏
https://doi.org/10.1249/MSS.0000000000000372‏

12. Hillebrand JJG, De Wied D, Adan RAH. Neuropeptides, food intake and body weight regulation: a hypothalamic focus. Peptides, 2002; 23.12: 2283-2306.‏‏
https://doi.org/10.1016/S0196-9781(02)00269-3

13. Inui A. Transgenic approach to the study of body weight regulation. Pharmacological reviews, 2000; 52(1): 35-62.‏

14. Carnier J, de Mello MT, Ackel-D́Elia C, Corgosinho FC, da Silveira Campos RM, de Lima Sanches P, et al. Aerobic training (AT) is more effective than aerobic plus resistance training (AT+ RT) to improve anorexigenic/orexigenic factors in obese adolescents. Appetite, 2013; 69: 168-173.‏
https://doi.org/10.1016/j.appet.2013.05.018

15. Ghanbari-Niaki A, Abednazari H, Tayebi SM, Hossaini-Kakhak A, Kraemer RR. Treadmill training enhances rat agouti-related protein in plasma and reduces ghrelin levels in plasma and soleus muscle. Metabolism, 2009, 58(12): 1747-1752.‏
https://doi.org/10.1016/j.metabol.2009.06.002

16. Ghanbari-Niaki A, Nabatchian S, Hedayati M. Plasma agouti-related protein (AGRP), growth hormone, insulin responses to a single circuit-resistance exercise in male college students. Peptides, 2007; 28(5): 1035-1039.‏
https://doi.org/10.1016/j.peptides

17. Bailey DP, Smith LR, Chrismas BC, Taylor L, Stensel DJ, Deighton K, et al. Appetite and gut hormone responses to moderate-intensity continuous exercise versus high-intensity interval exercise, in normoxic and hypoxic conditions. Appetite, 2015; 89: 237-245.‏
https://doi.org/10.1016/j.appet.2015.02.019

18. Miguet M, Fillon A, Khammassi M, Masurier J, Julian V, Pereira B, et al. Appetite, energy intake and food reward responses to an acute High Intensity Interval Exercise in adolescents with obesity. Physiology & behavior, 2018; 195: 90-97.‏
https://doi.org/10.1016/j.physbeh.2018.07.018

19. Thivel D, Isacco L, Montaurier C, Boirie Y, Duché P, Morio B. The 24-h energy intake of obese adolescents is spontaneously reduced after intensive exercise: a randomized controlled trial in calorimetric chambers. PLoS One, 2012; 7(1): e29840.‏
https://doi.org/10.1371/journal.pone.0029840

20. Flint A, Raben A, Blundell JE, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. International journal of obesity, 2000; 24(1): 38.‏
21. Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes. 2008; 32(9): 1431- 1437.
https://doi.org/10.1038/ijo.2008.102

22. King JA. Effects of exercise on appetite, food intake and the gastrointestinal hormones Ghrelin and Peptide YY. [PhD Thesis]. 2010.

23. De Rijke CE, Hillebrand JJG, Verhagen LAW, Roeling TAP, Adan RAH. Hypothalamic neuropeptide expression following chronic food restriction in sedentary and wheel-running rats. Journal of molecular endocrinology, 2005; 35(2): 381-390.‏
https://doi.org/10.1677/jme.1.01808

24. Katsuki A, Sumida Y, Gabazza EC, Murashima S, Tanaka T, Furuta M, et al. Plasma levels of agouti-related protein are increased in obese men. The Journal of Clinical Endocrinology & Metabolism, 2001; 86(5): 1921-1924.‏
https://doi.org/10.1210/jcem.86.5.7458

25. Shen CP, Wu KK, Shearman LP, Camacho R, Tota MR, Fong TM, Van der Ploeg LHT. Plasma agouti‐related protein level: a possible correlation with fasted and fed states in humans and rats. Journal of neuroendocrinology, 2002; 14(8): 607-610.‏
https://doi.org/10.1046/j.1365-2826.2002.00825.x

26. Ghanbari-Niaki A, Sharifi-Rigi AAH. Serum agouti--related protein (AGRP) response to a single session of circuit-resistance exercise at different intensities in male college students. Journal of applied exercise physiology, 2009; 55-63.‏

27. Qian, S, Chen H, Weingarth, D, Trumbauer ME, Novi DE, Guan, et al. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Molecular and cellular biology, 2002; 22(14): 5027-5035.
https://doi.org/10.1128/MCB.22.14.5027-5035.2002

28. Lu XY, Shieh KR, Kabbaj M, Barsh GS, Akil H, Watson SJ. Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake. Endocrinology, 2002; 143.10: 3905-3915. https://doi.org/10.1210/en.2002-220150

29. King NA, Burley VJ, Blundell JE. Exercise-induced suppression of appetite: effects on food intake and implications for energy balance. European journal of clinical nutrition, 1994; 48(10): 715-724.‏

30. Howe S, Hand T, Larson-Meyer D, Austin K, Alexander B, Manore M. No effect of exercise intensity on appetite in highly-trained endurance women. Nutrients, 2016; 8(4): 223.‏
https://doi.org/10.3390/nu8040223

31. Wirth MM, Giraudo SQ. Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding. Peptides, 2000; 21(9): 1369-1375.‏
https://doi.org/10.1016/S0196-9781(00)00280-1

32. Sim AY, Wallman KE, Fairchild TJ, Guelfi KJ. High-intensity intermittent exercise attenuates ad-libitum energy intake. International journal of obesity, 2014; 38(3): 417.‏
https://doi.org/10.1038/ijo.2013.102‏
33. Westerterp-Plantenga MS, Verwegen CR, IJedema MJ, Wijckmans NE, Saris WH. Acute effects of exercise or sauna on appetite in obese and nonobese men. Physiology & behavior, 1997; 62(6): 1345-1354.‏
https://doi.org/10.1016/S0031-9384(97)00353-3

34. George VA, Morganstein A. Effect of moderate intensity exercise on acute energy intake in normal and overweight females. Appetite, 2003; 40(1): 43-46.‏
https://doi.org/10.1016/S0195-6663(02)00146-0

35. Erdmann J, Tahbaz R, Lippl F, Wagenpfeil S, Schusdziarra V. Plasma ghrelin levels during exercise—effects of intensity and duration. Regulatory peptides, 2007; 143(1-3): 127-135. ‏
https://doi.org/10.1016/j.regpep.2007.05.002

36. Shorten AL, Wallman KE, Guelfi KJ. Acute effect of environmental temperature during exercise on subsequent energy intake in active men. The American journal of clinical nutrition, 2009; 90(5): 1215-1221.‏
https://doi.org/10.3945/ajcn.2009.28162

37. Martins C, Morgan LM, Bloom SR, Robertson MD. Effects of exercise on gut peptides, energy intake and appetite. Journal of Endocrinology, 2007; 193(2): 251-258.‏
https://doi.org/10.1677/JOE-06-0030

38. Tremblay A, Drapeau V. Physical activity and preference for selected macronutrients. Medicine and science in sports and exercise, 1999; 31(11 Suppl): S584-9.‏
https://doi.org/10.1097/00005768-199911001-00016

39. Elder SJ, Roberts SB. The effects of exercise on food intake and body fatness: a summary of published studies. Nutrition reviews, 2007; 65(1): 1-19.‏
https://doi.org/10.1111/j.1753-4887.2007.tb00263.x
Published
2020-08-30
How to Cite
1.
Khalaj S, Mirzaei B. Does an acute bout of high intensity interval exercise suppress appetite in obese women?. Pedagogy of Physical Culture and Sports. 2020;24(4):181-8. https://doi.org/10.15561/26649837.2020.0405
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