The effect of a placebo on strength performance in children
Keywords:
fitness, exercise, placebo effect, children, strengthAbstract
Background and study aim. Placebo responses are a well-known psychophysiological phenomenon observed in various areas of human performance. In the context of physical activity, these responses can influence motivation, perceived exertion, and measurable motor outcomes in both adults and children. Although placebo strategies are used in different practical settings, their relative effectiveness in enhancing strength performance in children remains a subject of practical interest. This study examined the impact of placebo administration on strength-related outcomes in children. Materials and Methods. Ninety-two participants (mean age 10.4 years) were randomly assigned to a placebo group (n = 47) or a control group (n = 45). The placebo group received a sweet-tasting liquid accompanied by a verbal suggestion of performance enhancement. Performance was assessed using a pull-up hold, handgrip strength, a wall-sit hold, and the standing broad jump. Results. Within-group analyses showed improvements in both groups for the pull-up hold (Control: p = 0.044, d = 0.39; Placebo: p < 0.001, d = 0.42). Only the placebo group showed significant gains in right-hand grip strength (+2.8 kg, p < 0.001, d = 0.73), left-hand grip strength (+2.0 kg, p < 0.001, d = 0.57), and the wall-sit hold (+21.3 s, p = 0.001, d = 0.52). Between-group comparisons showed significant advantages for the placebo group in right-hand grip strength (p < 0.001, d = 0.79) and in the standing broad jump (p = 0.008, d = 0.58). There were no significant differences in the other outcomes. Conclusions. The findings indicate that placebo interventions in children may preferentially enhance strength-endurance tasks, with less consistent effects on explosive performance. The improvement in handgrip strength, particularly in the right hand, suggests that placebo mechanisms may also influence measures of maximal strength.References
Frisaldi E, Shaibani A, Benedetti F. Understanding the mechanisms of placebo and nocebo effects. Swiss Medical Weekly, 2020;150(3536): w20340. https://doi.org/10.4414/smw.2020.20340
Niazi SK. Placebo Effects: Neurological Mechanisms Inducing Physiological, Organic, and Belief Responses—A Prospective Analysis. Healthcare, 2024;12(22): 2314. https://doi.org/10.3390/healthcare12222314
Oken BS. Placebo effects: clinical aspects and neurobiology. Brain, 2008;131(11): 2812–2823. https://doi.org/10.1093/brain/awn116
Ortega Á, Salazar J, Galban N, Rojas M, Ariza D, Chávez-Castillo M, et al. Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy. International Journal of Molecular Sciences, 2022;23(8): 4196. https://doi.org/10.3390/ijms23084196
Chen C, Niehaus JK, Dinc F, Huang KL, Barnette AL, Tassou A, et al. Neural circuit basis of placebo pain relief. Nature, 2024;632(8027): 1092–1100. https://doi.org/10.1038/s41586-024-07816-z
Petrovic P, Kalso E, Petersson KM, Ingvar M. Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network. Science, 2002;295(5560): 1737–1740. https://doi.org/10.1126/science.1067176
Colloca L, Benedetti F. How prior experience shapes placebo analgesia. Pain, 2006;124(1): 126–133. https://doi.org/10.1016/j.pain.2006.04.005
Hurst P, Schipof‐Godart L, Szabo A, Raglin J, Hettinga F, Roelands B, et al. The Placebo and Nocebo effect on sports performance: A systematic review. European Journal of Sport Science, 2020;20(3): 279–292. https://doi.org/10.1080/17461391.2019.1655098
Pollo A, Carlino E, Benedetti F. The top‐down influence of ergogenic placebos on muscle work and fatigue. European Journal of Neuroscience, 2008;28(2): 379–388. https://doi.org/10.1111/j.1460-9568.2008.06344.x
St Clair Gibson A, Swart J, Tucker R. The interaction of psychological and physiological homeostatic drives and role of general control principles in the regulation of physiological systems, exercise and the fatigue process – The Integrative Governor theory. European Journal of Sport Science, 2018;18(1): 25–36. https://doi.org/10.1080/17461391.2017.1321688
Inzlicht M, Marcora SM. The Central Governor Model of Exercise Regulation Teaches Us Precious Little about the Nature of Mental Fatigue and Self-Control Failure. Frontiers in Psychology, 2016;7. https://doi.org/10.3389/fpsyg.2016.00656
Beedie CJ, Foad AJ. The Placebo Effect in Sports Performance: A Brief Review. Sports Medicine, 2009;39(4): 313–329. https://doi.org/10.2165/00007256-200939040-00004
Filip-Stachnik A, Krzysztofik M, Kaszuba M, Leońska-Duniec A, Czarny W, Del Coso J, et al. Placebo Effect of Caffeine on Maximal Strength and Strength Endurance in Healthy Recreationally Trained Women Habituated to Caffeine. Nutrients, 2020;12(12): 3813. https://doi.org/10.3390/nu12123813
Kalasountas V, Reed J, Fitzpatrick J. The Effect of Placebo-Induced Changes in Expectancies on Maximal Force Production in College Students. Journal of Applied Sport Psychology, 2007;19(1): 116–124. https://doi.org/10.1080/10413200601123736
Maganaris CN, Collins D, Sharp M. Expectancy Effects and Strength Training: Do Steroids Make a Difference? The Sport Psychologist, 2000;14(3): 272–278. https://doi.org/10.1123/tsp.14.3.272
Weimer K, Gulewitsch MD, Schlarb AA, Schwille-Kiuntke J, Klosterhalfen S, Enck P. Placebo effects in children: a review. Pediatric Research, 2013;74(1): 96–102. https://doi.org/10.1038/pr.2013.66
Faria V, Linnman C, Lebel A, Borsook D. Harnessing the Placebo Effect in Pediatric Migraine Clinic. The Journal of Pediatrics, 2014;165(4): 659–665. https://doi.org/10.1016/j.jpeds.2014.06.040
Meister R, Abbas M, Antel J, Peters T, Pan Y, Bingel U, et al. Placebo response rates and potential modifiers in double-blind randomized controlled trials of second and newer generation antidepressants for major depressive disorder in children and adolescents: a systematic review and meta-regression analysis. European Child & Adolescent Psychiatry, 2020;29(3): 253–273. https://doi.org/10.1007/s00787-018-1244-7
Rheims S, Cucherat M, Arzimanoglou A, Ryvlin P. Greater Response to Placebo in Children Than in Adults: A Systematic Review and Meta-Analysis in Drug-Resistant Partial Epilepsy. Klassen T (ed.) PLoS Medicine, 2008;5(8): e166. https://doi.org/10.1371/journal.pmed.0050166
Cohen D, Consoli A, Bodeau N, Purper-Ouakil D, Deniau E, Guile JM, et al. Predictors of Placebo Response in Randomized Controlled Trials of Psychotropic Drugs for Children and Adolescents with Internalizing Disorders. Journal of Child and Adolescent Psychopharmacology, 2010;20(1): 39–47. https://doi.org/10.1089/cap.2009.0047
Cai LL, Li X, Cai QH, Guo SX, Zhang Y, Sun WC, et al. Irritable bowel syndrome in children: the placebo response rate and influencing factors a meta-analysis. Pediatric Research, 2024;95(6): 1432–1440. https://doi.org/10.1038/s41390-023-02996-2
Czerniak E, Oberlander TF, Weimer K, Kossowsky J, Enck P. “Placebo by Proxy” and “Nocebo by Proxy” in Children: A Review of Parents’ Role in Treatment Outcomes. Frontiers in Psychiatry, 2020;11: 169. https://doi.org/10.3389/fpsyt.2020.00169
Żegleń M, Kryst Ł, Bąbel P. Want to be fit? Start with your mind! The role of the placebo effect in physical fitness in children: a preliminary systematic review and meta-analysis. International Journal of Obesity, 2024;48(2): 177–187. https://doi.org/10.1038/s41366-023-01413-2
Fanti-Oren S, Birenbaum-Carmeli D, Eliakim A, Pantanowitz M, Nemet D. The effect of placebo on endurance capacity in normal weight children – a randomized trial. BMC Pediatrics, 2019;19(1): 15. https://doi.org/10.1186/s12887-019-1394-x
Fanti‐Oren S, Birenbaum‐Carmeli D, Nemet D, Pantanowitz M, Eliakim A. Significant effect of information placebo on exercise test results in children with normal weight, overweight and obesity. Acta Paediatrica, 2020;109(2): 381–387. https://doi.org/10.1111/apa.14959
Stopper M, Wabnegger A, Schienle A. Placebo Effects on the Enjoyment of Physical Activity and Performance among Kindergarten Children: A Randomized Controlled Trial. European Journal of Investigation in Health, Psychology and Education, 2024;14(8): 2435–2444. https://doi.org/10.3390/ejihpe14080161
Dotan R. Children’s Aerobic Trainability and Related Questions. Research Quarterly for Exercise and Sport, 2017;88(4): 377–383. https://doi.org/10.1080/02701367.2017.1371546
Kriketos A, Baur L, O’Connor J, Carey D, King S, Caterson I, et al. Muscle fibre type composition in infant and adult populations and relationships with obesity. International Journal of Obesity, 1997;21(9): 796–801. https://doi.org/10.1038/sj.ijo.0800476
Deli CK, Fatouros IG, Paschalis V, Georgakouli K, Zalavras A, Avloniti A, et al. A Comparison of Exercise-Induced Muscle Damage Following Maximal Eccentric Contractions in Men and Boys. Pediatric Exercise Science, 2017;29(3): 316–325. https://doi.org/10.1123/pes.2016-0185
Szabo A. Placebo effects on kayak sprint performance in child athletes. European Journal of Sport Science, 2024;24(5): 577–586. https://doi.org/10.1002/ejsc.12065
Burke MV, Small DM. Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism. Physiology & Behavior, 2015;152: 381–388. https://doi.org/10.1016/j.physbeh.2015.05.036
De Salles Painelli V, Fernandes E, Brietzke C, Pires FO. The placebo effect of a pink non-caloric, artificially sweetened solution on strength endurance performance and psychological responses in trained individuals. Nutrition and Health, 2025;31(2): 545–552. https://doi.org/10.1177/02601060231196590
Scholey AB, Kennedy DO. Cognitive and physiological effects of an ?energy drink?: an evaluation of the whole drink and of glucose, caffeine and herbal flavouring fractions. Psychopharmacology, 2004;176(3–4): 320–330. https://doi.org/10.1007/s00213-004-1935-2
Cadenas-Sanchez C, Martinez-Tellez B, Sanchez-Delgado G, Mora-Gonzalez J, Castro-Piñero J, Löf M, et al. Assessing physical fitness in preschool children: Feasibility, reliability and practical recommendations for the PREFIT battery. Journal of Science and Medicine in Sport, 2016;19(11): 910–915. https://doi.org/10.1016/j.jsams.2016.02.003
Morrow JR, Martin SB, Jackson AW. Reliability and Validity of the FITNESSGRAM®: Quality of Teacher-Collected Health-Related Fitness Surveillance Data. Research Quarterly for Exercise and Sport, 2010;81(sup3): S24–S30. https://doi.org/10.1080/02701367.2010.10599691
Foley RCA, Callaghan DH, Forman GN, Graham JD, Holmes MWR, La Delfa NJ. A comprehensive scoping review and meta-analysis of upper limb strength asymmetry. Scientific Reports, 2025;15(1): 4636. https://doi.org/10.1038/s41598-025-87413-w
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